Osteocalcin as an indicator
Bones are continuously undergoing a dynamic process of resorption and absorption known as bone metabolism.
Signaling pathways on which bone metabolism rely include the action of several hormones, including Osteocalcin, parathyroid hormone (PTH) and Vitamin D. As Osteocalcin, the major non-collagenousprotein of the bone matrix, is manufactured by osteoblasts, it is often used as a biochemical marker, for the bone formation process.
A large number of studies indicate that serumosteocalcin levels reflect very well the rate of bone formation. The determination of blood levels of Osteocalcin is valuable for the identification of women at risk of developing osteoporosis Monitoring bone metabolism in several clinical conditions:
- During peri- and post menopause;
- During Hormone Replacement Therapy;
- Patients with GH deficiency, Renal osteodystrophy.