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T3-Uptake, RIA, 100 tests

Thyroid hormones exert powerful regulatory influences on growth, differentiation, cellular metabolism and general hormonal balance of the body. Thyroxine (T4) and 3,5,3'-triiodothyronine (T3) circulate in the bloodstream principally bound to Thyroxine Binding Globulin (TBG)1. However, a very small proportion of each hormone exists in the free state2. Free T4 and free T3 are the substances which actually penetrate cell membranes and interact with the receptor surfaces of cell structures3. Free T4 and free T3 also act to inhibit the synthesis and release of thyroidstimulating hormone (TSH) by the pituitary gland4. Any change in the ability of the TBG in a patient's serum to bind T3 and T4 will result in a proportionate change in the amount of free hormones. In hyperthyroidism, the patient's TBG is more saturated, allowing excessive levels of T3 and T4 to remain in a free state. In hypothyroidism, the less saturated TBG prohibits adequate free hormone levels. The measurement of the unsaturated binding capacity of TBG by an uptake assay can therefore aid in evaluating thyroid gland function.

Catalog # 06B237116
Format RIA
Label I125
Size 100 tests
Sample Type Serum
Sample Volume 25 µL
Incubation 1 h RT with shaking
Shelf Life (weeks) 7

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CLOSING DAYS 2019 : 1/01-22/04-01&30/05-10/06-21/07-15/08-01&11/11-25/12

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DIAsource ImmunoAssays (formerly BioSource), experienced diagnostic manufacturer of RIA-ELISA-LIA immunoassays, validation on automates, large scale production of Antibodies-Point of Care Tests.

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