Acetylcholine Receptor

Myasthenia gravis (MG) is a skeletal muscle disorder characterized by muscular weakness. In such cases, muscular weakness is due to anti-acetylcholine receptor (AChR) antibodies. Anti-AChR antibodies are present in approximately 90% of patients with MG. Anti-AChR antibodies could be: binding antibodies (multitudes of wide populations of antibodies directed to hydrophilic domains of receptors), blocking antibodies (preventing binding of acetylcholine to receptors) and modulating antibodies (accelerating endocytosis resulting in loss of receptors).