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Insulin (INS)

Insulin, a polypeptide hormone with a molecular weight of 5800, is secreted by the beta cells of the islets of Langerhans from the pancreas. Insulin possesses a wide spectrum of biological actions. It stimulates cellular glucose uptake, glucose oxydation, glycogenesis, lipogenesis, proteogenesis and the formation of DNA and RNA. Insulin plays a key role in the regulation of plasma glucose levels (hepatic output inhibition, stimulation of peripheral glucose utilisation) continued....

Clinical application of insulin determination

  • Determination of the beta-cell reserve during glucose tolerance test or after a carbohydrate rich meal, as a guide for the instauration of insulin therapy
  • Contribution to the diagnosis of insulin and non-insulin-dependent diabete
  • Characterisation and follow-up of states of glucose intolerance
  • Diagnosis and study of cases of insulin resistance
  • Diagnosis of insulinoma and other causes of hypoglycemia
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